The Yeast Synthetic Biology Workshop took place on Saturday October 16, 2010 at UC San Francisco's Genentech Hall. Generously supported by Life Technologies, this one-day workshop was in response to a growing recognition that yeast is re-emerging as an important workhorse system in synthetic biology research-development-production processes, in particular for chemical production and biofuels applications. While many tools and technologies exist in yeast from basic research and applied development, there are opportunities to adapt existing tools, and to develop and standardize new tools to better meet the needs of scale, complexity and engineering in synthetic biology.

NOW AVAILABLE ONLINE: Videos of the presentations

Yeast Synbio Workshop - Geoff Duyk keynote (part 1).

Keynote speaker:
Geoff Duyk, TPG Ventures
"Lost in Translation: The Myth of Technological Determinism"
Duyk was previously President of Research & Development at Exelixis, and a founding scientist at Millennium Pharmaceuticals.

Workshop Format: A full day workshop focusing upon yeast synthetic biology tools and applications. Following the keynote talk, the workshop will proceed in three sequential sessions:

Genome engineering, approaches and tools:

• Dan Gibson (JCVI): Assembling and Engineering Bacterial Genomes in Yeast
• Zach Serber (Amyris): The Industrialization of Synthetic Biology: Rapid Yeast Strain Engineering
• Jef Boeke (Johns Hopkins): Building Saccharomyces cerevisiae 2.0: Probing Genome Plasticity

Engineering metabolic and regulatory pathways:

• Kirsten Benjamin (Amyris): Microbially-Derived Artemisinin: Engineering Yeast Using Synthetic Biology to Stabilize the Supply of an Important Anti-malarial Drug for the Developing World
• Sergio Peisajovich (UCSF): Signaling Network Engineering by Combinatorial Recombination
• Quinn Zhu (Dupont): Systemic Engineering of Yarrowia lipolytica for Production of Commercial Products

Fermentation, process development and production:

• Danie La Grange (University of Stellenbosch): Engineering Saccharomyces cerevisiae for Consolidated Bioprocessing
• Ton van Maris (Technical University of Delft): Engineering of Saccharomyces cerevisiae for Efficient Alcoholic Fermentation of Plant Biomass Hydrolysates
• Mickel Jansen (DSM): Yeast as an Industrial Platform for Fermentation Processes: Succinic Acid - A Case Study

At the conclusion of the three sessions, there will be a wine and hors d'ouevres social hour, followed by topical dinners aligned to the session themes and coordinated by the session chairs. These dinners are working sessions involving workshop participants to identify the key synthetic biology needs and opportunities in the session area. At the conclusion of the topical dinners, workshop participants will reconvene for session chairs to report out on the discussion and recommendations for needs and opportunities back to the workshop participants.

Participation: Workshop participants was limited to a small, high-caliber group from academic and applied research, industrial research, development and production areas such as local and national synthetic biology, chemical production, biofuels and fermentation research and production labs.

Sponsors:

• Life Technologies
• Synthetic Biology Engineering Research Center (SynBERC)

Organizing Committee:

Leonard Katz, SynBERC Research Director and Industrial Liaison Officer
Jay Keasling, SynBERC Director, UCB, LBL and JBEI
Todd Peterson, VP R&D, Life Technologies, SynBERC IAB Chair
Chris Paddon, Amyris
Jasper Rine, UCB, HHMI
Wendell Lim, UCSF, HHMI, SynBERC PI
Maitreya Dunham, University of Washington, SynBERC SAB
Pamela Silver, Harvard University, SynBERC PI
Zach Serber, Amyris

Attachment	Size
Yeast Synthetic Biology Workshop Agenda.pdf	91.56 KB